Doctors Best Epicor is a natural immune-supportive compound that fits into the unique category of being a high metabolite immunogen. EpiCor is a nutritive dried yeast fermentate that supports cellular metabolism and modulates immune function. It is derived from the yeast Saccharomyces cerevisiae, a non-pathogenic yeast commonly used in baking and brewing. In vitro laboratory data has shown that EpiCor beneficially influences cellular processes that impact immune health. EpiCor is an all-natural dietary supplement for ongoing immune system support. This novel supplement is a high metabolite immunogen, a complex blend of nutrients with a fascinating history of development. Since 1943, a company in Cedar Rapids, Iowa called Diamond V has been manufacturing a fermentation product from Saccharomyces cerevisiae, the harmless yeast used in bread and beer making. Their product is an animal feed additive used to improve the digestion and overall health of farm animals. By 2004, there were indications it might also benefit human health. The company noticed that employees who worked in its manufacturing plant had unusually low sick leave rates and made fewer health insurance claims than employees of similarly sized companies.1 The company commissioned a study, which confirmed that workers who had ongoing contact with the product had better immune system status than unexposed workers. Further research resulted in the development of EpiCor.
Doctor's Best - EpiCor . - 60 Vegetarian Capsules Serving Size: 1 Capsule- EpiCor dried yeast fermentate 500 mg. Other Ingredients: Modified cellulose (vegetarian capsule), cellulose, magnesium stearate (vegetable source), silicon dioxide
Take one capsule daily with or without food.
Safety Warning :
Numerous safety tests have been conducted on EpiCor, revealing an extremely safe profile. Animal studies performed by a leading toxicology laboratory showed no indication of any toxic effects of EpiCor. An acute oral toxicity study on 20 rats showed that the product was safe when given to rats at a single oral dose of 2000 milligrams per kilogram of body weight (equivalent to a human ingesting 280 capsules at once). After 2 weeks the rats showed no clinical symptoms, no deaths, no abnormalities in body weight, and no gross pathological changes. The same safety results were found in a subchronic toxicity study where rats were given up to 1500 milligrams daily for 90 days (equivalent to a human ingesting up to 210 capsules daily for 1.5 years). Again, absolutely no signs or symptoms of toxicity were noted in these animals.In addition, a standard bacterial reverse mutagenicity test (AMES test) as well as a mammalian cell mutation assay using mouse lymphoma cells revealed no evidence of any increase in mutation rates after exposure to EpiCor. EpiCor also showed no evidence of mitogenicity (inducing increased cell division) in a human lymphocyte proliferation assay. This suggests that EpiCor does not cause over-reactivity of cells.The effect of EpiCor on specific liver enzymes CYP1A2 and CYP3A4 (enzymes involved in metabolizing certain drugs and other compounds) was assessed. Immortalized hepatocytes (liver cells) were treated with various concentrations of EpiCor and compared to both positive and negative controls. EpiCor did not increase the expression or activity of the liver enzymes, suggesting that it may not affect the metabolism of other substances or medications metabolized by these enzymes if they are taken simultaneously. It also did not appear to be toxic to the cells as measured by lactate dehydrogenase assays and microscopic analysis.Lastly, EpiCor was tested for safety in humans in an open label study on 15 adult men and women given a single 500 milligram dose for 30 days. On various days throughout the study vital signs were monitored, and blood and urine samples were analyzed. No clinically relevant abnormal effects on the participants were found.EpiCor also currently has received self-affirmed Generally Regarded as Safe (GRAS) status by an expert panel that included eminent toxicologists.EpiCor is a novel compound with an incredibly unique composition that has been shown to enhance immune system function.
Legal Statement :
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease